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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMED8
All Species:
18.48
Human Site:
S181
Identified Species:
33.89
UniProt:
Q6PL24
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6PL24
NP_998766.1
325
35740
S181
K
L
G
K
E
K
N
S
R
L
V
V
K
R
G
Chimpanzee
Pan troglodytes
XP_001164357
325
35736
S181
K
L
G
K
E
K
N
S
R
L
V
V
K
R
G
Rhesus Macaque
Macaca mulatta
XP_001091471
528
60518
S393
K
I
Q
Q
D
A
D
S
V
I
T
V
G
R
G
Dog
Lupus familis
XP_547929
298
33533
I166
K
R
G
E
V
V
T
I
R
V
P
T
H
P
E
Cat
Felis silvestris
Mouse
Mus musculus
Q3UHI4
326
35767
S182
K
L
G
K
E
K
N
S
R
L
V
V
K
R
G
Rat
Rattus norvegicus
Q7TNY6
526
60461
S390
K
I
R
Q
D
A
D
S
V
I
T
V
R
R
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512836
477
55503
S342
K
I
R
Q
D
A
D
S
V
I
T
V
G
R
G
Chicken
Gallus gallus
NP_001026377
214
24186
V82
V
V
K
R
G
E
V
V
T
V
R
V
P
T
H
Frog
Xenopus laevis
NP_001089743
231
26366
V99
L
T
V
R
R
G
E
V
L
T
V
R
V
P
T
Zebra Danio
Brachydanio rerio
NP_001018152
264
29108
D132
V
V
T
V
Y
R
G
D
I
M
T
V
H
V
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_608348
480
55039
G330
V
S
A
G
D
G
D
G
V
I
T
I
G
H
G
Honey Bee
Apis mellifera
XP_394773
464
53929
A313
I
R
R
E
D
S
D
A
V
I
K
V
G
H
G
Nematode Worm
Caenorhab. elegans
NP_001041026
396
45028
G237
I
K
K
D
G
H
E
G
I
I
K
V
G
H
G
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
29.1
80.3
N.A.
85.8
29.8
N.A.
30.6
52
45.8
42.4
N.A.
26.2
26.7
31.5
N.A.
Protein Similarity:
100
100
42.6
86.1
N.A.
89.8
42.7
N.A.
43.6
60.3
58.1
57.5
N.A.
42.5
43.5
45.7
N.A.
P-Site Identity:
100
100
33.3
20
N.A.
100
33.3
N.A.
33.3
6.6
6.6
6.6
N.A.
6.6
13.3
13.3
N.A.
P-Site Similarity:
100
100
66.6
33.3
N.A.
100
73.3
N.A.
66.6
33.3
13.3
26.6
N.A.
33.3
46.6
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
0
24
0
8
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
39
0
39
8
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
16
24
8
16
0
0
0
0
0
0
0
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
31
8
16
16
8
16
0
0
0
0
39
0
70
% G
% His:
0
0
0
0
0
8
0
0
0
0
0
0
16
24
8
% H
% Ile:
16
24
0
0
0
0
0
8
16
47
0
8
0
0
0
% I
% Lys:
54
8
16
24
0
24
0
0
0
0
16
0
24
0
0
% K
% Leu:
8
24
0
0
0
0
0
0
8
24
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
24
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
8
0
8
16
8
% P
% Gln:
0
0
8
24
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
16
24
16
8
8
0
0
31
0
8
8
8
47
0
% R
% Ser:
0
8
0
0
0
8
0
47
0
0
0
0
0
0
0
% S
% Thr:
0
8
8
0
0
0
8
0
8
8
39
8
0
8
8
% T
% Val:
24
16
8
8
8
8
8
16
39
16
31
77
8
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _